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New route to enhance drug permeation

The permeation enhancing features of the NexACT technology has been demonstrated in the delivery of alprostadil (Vitaros), a topical drug recently approved by Health Canada to treat erectile dysfunction. The leading molecule of the NexACT technology, dodecyl-2-N,N-dimethylamino propionate hydrochloride (DDAIP.HCl), has been listed in regulatory filings as a functional non-active excipient. Application of this technology to optimise the pharmacokinetic parameters of a given drug has a tremendous commercial potential in the development of new and improved products with increased bioavailability. The mechanism of action, chemistry, toxicology and safety of these excipients along with typical examples for different routes of administration are reviewed in this paper.
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NexACT technology enables rectal delivery of biologics

Apricus reveals results of pre-clinical study
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