BAC and LFB Biotechnologies to develop custom ligand

Published: 28-May-2008

BAC, of the Netherlands, has entered into a collaboration with French biopharmaceutical company LFB Biotechnologies, a wholly owned subsidiary of LFB, to discover and develop a custom CaptureSelect ligand for the purification of a recombinant Factor VIIa product - an essential protein for certain blood coagulation disorders - developed by LFB with GTC Biotherapeutics.


BAC, of the Netherlands, has entered into a collaboration with French biopharmaceutical company LFB Biotechnologies, a wholly owned subsidiary of LFB, to discover and develop a custom CaptureSelect ligand for the purification of a recombinant Factor VIIa product - an essential protein for certain blood coagulation disorders - developed by LFB with GTC Biotherapeutics.

The CaptureSelect ligand has the potential to obtain high purity in downstream processing while enhancing the cost reduction benefits of the transgenic expression system developed by LFB and GTC. LFB and GTC are producing Factor VIIa in the milk of animals that express this recombinant protein during lactation.

BAC - the Bio Affinity Company - has a proven reputation for the rapid discovery and development of customised ligands for a wide range of affinity applications from the purification of monoclonal antibodies and viruses, to plasma proteins. CaptureSelect ligand technology is based on unique Camelid single chain antibody fragments, which can be selected for desirable chromatographic characteristics and produced at high-titre in a proprietary S. cerevisiae strain.

The CaptureSelect ligands are suitable and available for use at commercial biomanufacturing scale and for bench research.

"Our technology platform enables us to produce ligands that are not only highly specific for the target protein, but will generate a very pure product in a single purification step," said Laurens Sierkstra, ceo of BAC. "We are looking forward to working with LFB to develop a ligand for their recombinant Factor VIIa protein that will help to simplify and streamline the purification process."

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