Sartorius Stedim Biotech launches single-use harvesting technology

Published: 15-Apr-2015

Single-use clarification system eliminates centrifuges

Sartorius Stedim Biotech (SSB), a supplier to the biopharmaceutical industry, has added Sartoclear Dynamics, a clarification system featuring new single-use technology for harvesting mammalian cell cultures with high cell densities, to its portfolio.

Continuous improvements in growth media and cell lines have elevated biomass concentrations in bioprocesses and these increasingly higher concentrations are placing growing challenges on the purification process. As body feed filtration has proved to be the best solution to solve similar challenges in related industries, Sartorius Stedim Biotech has now developed this robust technology for biotech applications.

Designed for cGMP processing, Sartoclear Dynamics consists of prefilled single-use bags containing ultrapure diatomaceous earth (DE) in a choice of 0.5–10kg. With a new quick-connect adapter for dust-free powder transfer, DE can be directly mixed into the cell culture fluid. This porous filter aid is said to prevent blockage of the Sartoclear Dynamics filters. As the system maintains a constant ratio of biomass and filter aid, users will benefit from continuous maximum filter performance.

Consistent results, ease of use, speed and linear scalability are the key characteristics of the Sartoclear Dynamics technology, the company said.

Used in combination with precipitation, this technology transforms harvesting from a two-stage process into a single-stage operation, saving footprint and time.

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