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Manufacturing
Field Flow Fractionation application in MAB development
The protein species that aggregate during the production of MABs species need to be separated out, but traditional separation techniques, such as GPC/SEC, are often inappropriate due to the relatively delicate nature of biopharmaceutical species.
MABs are particularly susceptible to damaging shear effects encountered during interactive chromatographic separation. Field Flow Fractionation (FFF) is a highly sensitive technique that can gently and non-destructively separate aggregate protein species in MAB formulation