Multi-project agreement will research and develop first-in-class cancer drugs that modulate DNA damage and repair response (DDR) processes in cancer cells
Cancer Research Technology, Cancer Research UK’s technology development arm, and Teva Pharmaceutical Industries have signed a multi-project alliance agreement to research and develop first-in-class cancer drugs that modulate DNA damage and repair response (DDR) processes in cancer cells. DDR plays a key role in protecting cancer cells from the damaging effect of chemotherapy – creating an in-built antidote to the toxic effects of the antitumour drug. As the cancer cells that are best able to repair the DNA damage caused by the cancer treatments survive, they replicate, naturally selecting for the mutation with the enhanced repair capability – leading to recurrence and resistance to treatment.
Cancer Research UK and CRT has created a world-class hub of expertise in DDR-related basic, translational, and clinical research that is leading the field; building the understanding that will hopefully enable 'smarter' use of this very interesting approach in the development of new treatment options.
Based on Cancer Research UK's extensive network of leading UK universities, and its five cancer research institutes (Gray Institute, Oxford; Cancer Research UK Cambridge Institute; London Research Institute; Paterson Institute, Manchester; and the Beatson Institute, Glasgow), this hub will provide the foundations for CRT's and Teva's work towards developing novel therapies based on DDR-related targets for the treatment of cancer.
'For cancer patients, it is important that we maintain the momentum of progress that has been made in oncology in recent years,' said Dr Michael Hayden, President, Teva Global R&D and Chief Scientific Officer. 'This research collaboration will build on our understanding of how cells repair DNA damage, help us identify possible points of therapeutic intervention, and lead us onto a pathway toward improve clinical outcomes.'
For cancer patients, it is important that we maintain the momentum of progress that has been made in oncology in recent years
The alliance provides Teva with the opportunity to research and develop selected and differentiated novel treatments targeting DDR processes. With a focus on mechanisms and molecular targets related to the emergence of therapeutic resistance in cancer cells, the partnership also opens up the potential to expand the clinical utility and therapeutic effectiveness of Teva’s current portfolio of oncology chemotherapeutic agents. This approach builds on Teva’s growing focus on personalised medicine throughout its R&D pipeline, and specifically within its oncology portfolio.
Building on a prior well-established working relationship, the multi-year agreement sets out the provision of new molecular targets, selected by CRT from Cancer Research UK’s portfolio of biological research in DDR. These targets will be validated to prove their therapeutic importance before progressing to the early stages of drug discovery in CRT’s Discovery Laboratories. CRT and Teva will then jointly undertake chemical lead generation activities.
Under the terms of the agreement, CRT will receive research funding and be eligible to receive milestone payments, and royalties on projects advancing through Teva’s drug pipeline.
'Cancer Research UK scientists are carrying out exciting research in the area of DNA damage repair,' said Dr Hamish Ryder, director of drug discovery at CRT’s Discovery Laboratories. 'Finding new ways to block repair in tumours can boost the effectiveness of existing therapies. 'This exciting alliance with Teva brings together the cutting-edge research funded by Cancer Research UK, CRT’s expertise in progressing new drug targets and Teva’s drug research and development capabilities in a compelling partnership.'