Functionalised calcium carbonate: a next-generation mineral excipient

Published: 11-Oct-2016

With an extremely fast disintegration time and a high API loading capability, a newly developed excipient can be directly compressed into tablets that disintegrate in less than 10 seconds

Orally disintegrating tablets (ODTs) are a preferred dosage form compared with conventional tablets because of the numerous advantages they offer, such as rapid dissolution and fast onset of action.

To maintain the porous structure needed for fast dispersion, most current ODT formulations are limited by their mechanical strength. With functionalised calcium carbonate, however, pharmaceutical manufacturers can produce ODTs that offer high mechanical strength while disintegrating twice as fast as comparable tablets.

ODTs are becoming increasingly important in the pharmaceutical market, both for prescription and over-the-counter medications, and can significantly enhance patient compliance. As they can be swallowed without the need for water, these dosage forms are particularly convenient for children and the elderly, and they’re the delivery format of choice for people who want to take their medicine ‘on the go.’ They are also particularly helpful for patients who have difficulty swallowing — a complication associated with a number of age-related conditions, including stroke and Parkinson’s disease.

Production challenges

The development of ODTs is a demanding process that requires two seemingly contradictory product attributes: high porosity for fast disintegration and high mechanical strength to prevent tablet damage during processing. ODTs can be prepared using different techniques, such as freeze drying, moulding, spray drying or mass extrusion. The final form has to deliver active ingredients in a short timeframe; but, depending on the technique used, it may be associated with low mechanical strength, high production costs and inferior stability.

The preferred method of preparing ODTs, from the perspective of cost and simplicity, is direct compression. However, the disintegration capacity of ODTs produced in this way is limited by the size and hardness of the resulting tablets. Therefore, when compressing ODTs, the main concern is ensuring a structure that enables fast disintegration without compromising the hardness of the tablets.

Very often, ODTs with optimal disintegration characteristics are small and/or have a low hardness value and are highly friable. Further challenges when formulating ODTs include cost-intensive production processes such as freeze drying, which often results in a lack of physical resistance, which can cause packaging difficulties. With Omyapharm Functionalized Calcium Carbonate, Omya has developed an innovative excipient that overcomes all of these challenges and provides excellent hardness as well as fast disintegration times.

Porous but strong

Functionalized Calcium Carbonate (FCC) is manufactured from high purity calcium carbonate, which undergoes a surface recrystallisation process to create a structured mineral (Figures 1 and 2). This process can be controlled to obtain specific surface areas ranging between 30 and 180m2/g, a median particle size distribution of 2–30µm, and porosities of higher than 60%.

Figure 1: Micrograph of natural calcium carbonate

Figure 1: Micrograph of natural calcium carbonate

Figure 2: Micrograph of functionalised calcium carbonate

Figure 2: Micrograph of functionalised calcium carbonate

Omyapharm particles are characterised by an external lamellae structure and an internal network of interconnected pores. This structure facilitates the production of granules by dry granulation and, subsequently, tablets that feature both high porosity and high levels of hardness.

What’s also special about Omyapharm, compared with other porous excipients, is its lamellae morphology, which provides plenty of surface contact points among the particles — ensuring safe interlocking during dry granulation in roller compactors. This structure also contributes to greater tensile strength and preserves the porosity at compression forces that are lower than those needed for other excipients. High granular porosity is maintained, even at high compression forces, allowing for shorter disintegration times.

After milling and sieving, the granules are ready to be mixed with active pharmaceutical ingredients (APIs) and can be directly compressed into ODTs. Case studies have shown that FCC can be successfully loaded with an API content of up to 40%.1

Exceptional compressibility

In one study, researchers examined the compressibility of tablets made using FCC granules and compared them with tablets made with either FCC in powder form, conventional calcium carbonate, mannitol or microcrystalline cellulose (MCC).2

The scientists analysed the tensile strength and porosity of the tablets across a broad range of compression forces (Figures 3A and 3B). At a low compression pressure, the tensile strength of tablets formulated with FCC powder or FCC granules was higher than that of tablets formulated with mannitol or calcium carbonate and was comparable with that of tablets formulated with MCC. The FCC tablets also had a higher porosity than those containing the other excipients tested.

Figure 3A: Tensile strength versus mean compression pressure for tablets made using FCC and reference excipients. At lower compression pressures, FCC tablets reach tensile strengths higher than or comparable with that of tablets formulated with other reference excipients

Figure 3A: Tensile strength versus mean compression pressure for tablets made using FCC and reference excipients. At lower compression pressures, FCC tablets reach tensile strengths higher than or comparable with that of tablets formulated with other reference excipients

Figure 3B: Porosity versus mean compression pressure for tablets formulated with FCC or reference excipients. The starting porosity of FCC tablets is higher than that of tablets formulated with the reference excipients

Figure 3B: Porosity versus mean compression pressure for tablets formulated with FCC or reference excipients. The starting porosity of FCC tablets is higher than that of tablets formulated with the reference excipients

With FCC in the formulation, tablets were able to reach a comparable or higher hardness than other formulations at lower compression pressures, which allowed their porosity to remain higher than 50%. This provides a large volume of voids to accommode APIs.

In a second step, the researchers analysed tablets formulated with paracetamol and one of the following: FCC powder or MCC (Figures 3C and 3D). They concluded that despite the presence of an API, the decrease in porosity of the FCC tablets was significantly less than that of tablets formulated with MCC when compression pressure was increased. Additionally, the tensile strength of the FCC tablets was comparable with that of tablets formulated with MCC. Finally, the FCC tablets’ combination of high tensile strength and high porosity indicated that FCC is suitable for use in ODTs as a pharmaceutical excipient.3

Figure 3C: Tensile strength versus mean compression pressure for tablets formulated with paracetamol and one of the following: FCC powder or MCC. The tensile strength of FCC tablets was comparable with that of tablets formulated with MCC

Figure 3C: Tensile strength versus mean compression pressure for tablets formulated with paracetamol and one of the following: FCC powder or MCC. The tensile strength of FCC tablets was comparable with that of tablets formulated with MCC

Figure 3D: Porosity versus mean compression pressure of tablets formulated with paracetamol and one of the following: FCC powder or MCC. Despite the presence of an API, the decrease in porosity of the FCC tablets is significantly less than that of tablets formulated with MCC when the compression pressure increases

Figure 3D: Porosity versus mean compression pressure of tablets formulated with paracetamol and one of the following: FCC powder or MCC. Despite the presence of an API, the decrease in porosity of the FCC tablets is significantly less than that of tablets formulated with MCC when the compression pressure increases

ODT applications

To determine residence time, scientists at the University of Basel in Switzerland used a tensiometer to measure mass versus time, which, in turn, allowed them to study water uptake and disintegration behaviour. They analysed the disintegration kinetics of 24 different formulations and identified four patterns. Type I was considered to be ideal behaviour because it resembled the market formulation. Type II was characterised by very fast water uptake but no disintegration.

Type III disintegrated in discrete steps, resulting in tablet pieces, whereas Type IV disintegrated only partially. FCC exhibited a Type I disintegration pattern, and its residence time was half that of the market formulation used as a reference.

FCC’s direct compressibility into granules and its high porosity allow faster water uptake, leading to a disintegration time that is twice as fast as the market reference product. Orally disintegrating granules manufactured with FCC disintegrate in two seconds and their corresponding ODTs in less than 10 seconds.

One excipient with multiple benefits

The high porosity of ODTs formulated with FCC means that disintegration is rapid and even, so there is no need to use cost-intensive production equipment. With their high mechanical strength, ODTs formulated with FCC can be filled in regular bottles and blisters, which significantly reduces the cost and difficulty of packaging.

From a regulatory point of view, FCC also provides advantages: Omyapharm is a coprocessed excipient composed only of two monographed minerals and offers the possibility of multiple functionalities with very simple chemistry and a straightforward manufacturing process. Additionally, it is possible to tailor the characteristics of FCC, such as specific surface area, particle size distribution and pore size distribution, according to the requirements of various applications.

Furthermore, unlike many similar materials, FCC has the advantage of being highly biocompatible. Its composition is basically that of mineral bone material: hydroxyapatite and calcium carbonate. Bearing all of these issues in mind, Omyapharm is a very promising excipient that could revolutionise the ODT market. It will be interesting to see what kind of formulations this mineral-based ingredient will make possible in the near future.

References

1. D. Preisig, et al., ‘Drug Loading into Porous Calcium Carbonate Microparticles by Solvent Evaporation,’ Eur. J. Pharm. Biopharm. 87, 548–558 (2014).

2. T. Stirnimann, et al., ‘Compaction of Functionalized Calcium Carbonate: A Porous and Crystalline Microparticulate Material with a Lamellar Surface,’ Int. J. Pharm. 466(1–2), 266–275 (2014).

3. T. Stirnimann, et al., ‘Functionalized Calcium Carbonate as a Novel Pharmaceutical Excipient for the Preparation of Orally Dispersible Tablets,’ Pharm. Res. 30(7), 1915–1925 (2013).

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