Golden Staph tricked by vitamin mimic
Vitamins are good for our health, but what if we could use vitamins to treat infections as well?
Ashleigh Paparella at the University of Adelaide has discovered a new class of vitamin-like molecules that can be used to treat life-threatening ‘golden staph’ bacteria.
'Golden staph is a dangerous bacterium that is resistant to many common antibiotics,' said Ashleigh. 'We’ve discovered a new class of antibiotics that stops golden staph in its tracks by preventing its use of vitamin B7.'
Normally, golden staph picks up vitamin B7 from its environment and uses it as a co-factor to create energy for growth and metabolism. Ashleigh found that her antibiotic – which is a vitamin B7 mimic – prevents the normal activity of B7 by blocking the activity of an enzyme called BPL.
'We’ve also tested to show that our B7 mimic does not block BPL in human cells, so it is safe to use,' Ashleigh explained.
Although these studies have been conducted in cultured cells so far, Ashleigh is now measuring the capacity of the B7 mimic to treat real-life infections. 'Antibiotic resistance is a global threat to human health,' said Ashleigh, adding: 'We hope our research will help to tackle this important issue.'
Ashleigh presented her research at Fresh Science South Australia 2015. Fresh Science is a national programme that helps early-career researchers to find and share their stories of discovery.
