A new diverse library of screening compounds from Thermo Fisher Scientific is designed to maximise efficiency and productivity for researchers in early phase small molecule drug discovery.
By delivering diverse coverage of the space spanned by all possible drug-like molecules and associated characteristics, the Maybridge HitCreator library provides a greater hit probability than larger, but less diverse, screening libraries, the company says.
The Maybridge HitCreator library consists of 14,000 screening compounds selected for maximum diversity by rigorous analysis of more than 500,000 commercially available screening compounds. Each Maybridge HitCreator diversity library is available off the shelf and supplied as dry films in Thermo Scientific Matrix 96 shallow-well plates or 384-well microplates.
'Diversity-based screening is a vital tool for discovering new molecules that could potentially influence drug discovery. However, the wide range of commercially available screening libraries is daunting for scientists to pick the ideal library for their specific requirements,' said Simon Pearce, product marketing manager, Global Chemicals, Thermo Fisher Scientific.
'Our new Maybridge HitCreator library simplifies this challenge through its exceptional diversity. It removed the need to choose between different libraries and covers all drug-like chemical space to provide cost-effective hits reliability from a single library.'
Building on more than 50 years in designing libraries, all compounds within the Maybridge HitCreator are selected for a high hit probability. All are drug-like and conform to Lipinski’s 'Rule of Five', ensuring that they possess key physicochemical properties frequently found in orally active drugs, as well as additional filters.
