Thermo Fisher Scientific introduces ‘off the shelf’ fragment library
The Maybridge Ro3 Diversity Fragment Library contains a broad range of 1,500 compounds
Thermo Fisher Scientific has made the Maybridge Ro3 Diversity Fragment Library available in a new prepared format, with each compound pre-dissolved as a DMSO solution.
A gold standard for lead generation, the Maybridge Ro3 Diversity Fragment Library contains a broad range of 1,500 compounds, many of which are small-molecule pharmacophores available only from Maybridge. Manufactured and selected specifically to meet ‘Rule of Three’ requirements, these fragments are an ideal first step in pharmaceutical lead development.
The new ready-to-use format offers complete user convenience, saving time on sample and stock solution preparation. Available in three 500-compound sets, each compound in the library is pre-solubilised as a 1ml 10mM solution, providing 10µMol of 95% purity pharmacophore dissolved in analytical grade DMSO. The libraries are also available at higher concentrations upon request.
The Maybridge Ro3 Diversity Fragment Library is provided in standard, automation-compatible, matrix tube and latch-rack formats and is also available pre-packaged to fit any standard microplate footprint, with cap mat seals for automated, high-throughput applications.
Each compound has a Tanimoto similarity index of 0.66, allowing for superb structural diversity across the library. The library contains a large number of compound fragments that are linker friendly, enabling them to be incorporated into larger drug molecule backbones.
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