MicroConstants offers nanoparticle formulation service
MicroConstants\' nanosizing technology transforms water insoluble compounds into nanoparticles.
MicroConstants, a California, US-based GLP-compliant Contract Research Organisation (CRO) specialising in bioanalytical and pharmacokinetic analysis, is offering a nanosizing technology that transforms water insoluble compounds into nanoparticles, making formulation preparation and dosing for toxicology studies easier. In multiple cases, the company says its method increases the gastro-intestinal absorption of insoluble compounds ensuring maximal oral exposure for toxicology studies.
The patented, proprietary nanosizing process used at MicroConstants does not involve water or mechanical shear, and the company claims it is faster and more efficient than aqueous-based technologies. Furthermore, the process typically does not require the addition of excipients, leaving the pure Active Pharmaceutical Ingredient (API) ready for easy dispersion as a convenient suspension formulation.
The company claims the technique also provides higher dose loading (50-60%), and is amenable to all routes of extravascular administration. The particle size is reproducible and the process completely scalable, it says.
