Market Reports

Rethinking HPLC degassing with novel flat film technology

During the first three decades of liquid chromatography (LC) use, outgassing in the mobile phase was a key challenge in routine LC workflows. However, since the emergence of online degassers in the 1970s, these devices have become an ordinary component of most LC systems and, therefore, their development is often overlooked

Expanding globally: building on a European presence

To build the overseas presence of Federal Equipment Company and solidify our status as a global provider of equipment solutions, we have opened an office in the Netherlands, reports Paul Sombekke, European Business Development Manager

Granulation: an established technology in a changing world

Optimising the granulation process — the most important unit operation during the production of pharmaceutical oral solid dosage forms — is not only a critical aspect of operational excellence, it also plays a major role in preventing downstream compression problems

John Baker: life sciences need to address the reproducibility crisis

The head of product innovation at Abcam says it is crucial that the whole industry finds ways to de-risk the route to the patient as early as possible

Optimise desiccants with 3D validation software

Baltimore's CFD model brings predictive science to validation. Desiccants are tested for performance over time, bringing cost-efficiency to the forefront. Dr Mark Valentine explains

IntelGenx: oral films are drug development’s patent trick

Exploiting improvements in bioavailability, the Canadian company has developed unique oral film technology to help drugmakers secure exclusivity and financial returns

How to avoid sticking and picking in the tableting industry

John Norman and Kevin Queensen of Natoli Engineering explain

Super early bird tickets now on sale for Manufacturing Chemist Live 2020

Manufacturing Chemist Live will provide guidelines and regulations for delegates seeking solutions to optimise pharmaceutical production and safety in the manufacturing environment

Distributed control system reduces downtime for pharmaceutical manufacturer

In this case study, Rockwell Automation describes how Mallinckrodt Pharmaceuticals was able to streamline production and pinpoint potential bottlenecks by implementing a virtualised control system architecture

Flexibility through standardisation

The global pharmaceutical industry is going through a significant transformation, shifting from blockbuster drugs to personalised medicines based on biotechnology and genomics

There’s more than one way to produce pharmaceutical water

Bosch Packaging’s Susanne Handrick and Nils Ern examine the potential of cold membrane processes for the production of pharmaceutical water for injection

Winner of the Nobel Prize in Physiology or Medicine

William Kaelin Jr, Sir Peter Ratcliffe, and Gregg Semenza have won the Nobel Prize for Physiology or Medicine 2019 for their discoveries of how cells sense and adapt to oxygen availability

Medical cannabis made in Italy

Dr Fabio Di Francesco, a compounding pharmacist based in Rome, describes how cannabis is used in various dosage forms and the challenges ahead

Almac FAST: Continuous flow chemistry with assisted synthesis technology

Flow assisted synthesis technology (FAST) is a unique flow chemistry platform for continuous production of chemicals when batch-based processes fail to deliver the required quality of product

Peak identification by LC/MS: Automation versus analyst

High pressure liquid chromatography/mass spectrometry (LC/MS) is an important technique that facilitates the correct and accurate identification of impurities in pharmaceutical products and intermediates

Testing the limits of dosage production with continuous direct compression technology

GEA’s Dr James Holman, Head of New Development and Innovation, Pharma, discusses the process robustness and operational considerations of the company’s CDC 50 platform during a 120-hour trial run

Beximco Pharma: The Bangladeshi company connecting with the US

COO Rabbur Reza talks about the strategy behind approaching pharmaceutical manufacturing from an emerging market

Addressing the need for cost-effective vaccine manufacturing

Process intensification and integrated continuous bioprocessing are two approaches that can be used to achieve cost-effective, local production of high-quality biologic products. Tania Pereira-Chilima, Product Manager at Univercells, explains

Future market dynamics and opportunities in immuno-oncology

Long-term survival, tumour-agnostic effects and the potential for cure in a fraction of patients are key catalysts driving the explosion of research and recent approvals in IO. Dr Kevin Robinson recently caught up with SmartAnalyst’s Nidhi Dhingra and Jaideep V. Thottassery to delve a little deeper

A microfluidic approach to production of alginate beads for cell encapsulation

Gurinder Vinner, Material Scientist at Dolomite Microfluidics, discusses the benefits of continuous microfluidic production for the encapsulation of mammalian cells with no loss of viability

The case for single-use architecture in pharma

Billy Sisk, Life Sciences Industry Manager, EMEA, at Rockwell Automation recently contributed to the free downloadable e-book, the <i>Big Book of Biotech</i>, alongside input from GSK, Merck, ZeClinics and others. Here, for readers of <i>Manufacturing Chemist</i>, he picks up his topic of single-use facilities

Case Study: Phase I to commercial in 18 months

Gabor Heltovics, Druggability Technologies CEO, talks about using Quotient Sciences to progress and scale-up an improved pain relief drug formulation

Manufacturing misconceptions: The difficulties of tackling big data analysis

The advent of Industry 4.0 offers huge potential to explore new and exciting changes to the manufacturing floor, comments Dirk Ortloff, Department Manager, camLine

Guide to wash-in-place process in horizontal mixing systems

Modular solutions are proven to reliably fulfil any industry-specific requirements in the pharmaceutical, food, cosmetics, and chemical industries. Sebastian Steinkamp of Lödige provides a step-by-step guide to effective cleaning

Trending Articles

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    Overcoming the hurdles of strategic market expansion Ramprasad Kaparaboyena, Regulatory Affairs Manager and QP for Pharmacovigilance at Gaelic Laboratories, discusses how to overcome the challenges of expanding your pharma market into new global regions
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    Reimagining biosimilars: faster access, stronger supply, sustainable healthcare Outdated development models, uneven adoption and policy barriers are holding Europe back. Dr Kevin Robinson (KSR) spoke to Matt Erick (ME), Head of Advanced Markets at Biocon Biologics (pictured), to discover how the industry can close the biosimilars void and unlock billions in savings
  3. Reading and understanding vendor-supplied tablet drawings Understanding the tablet drawings supplied by tooling vendors is a meaningful way to learn more about your product, reports John Norman, Technical Service Representative, Natoli Engineering Company
  4. Peak identification by LC/MS: Automation versus analyst High pressure liquid chromatography/mass spectrometry (LC/MS) is an important technique that facilitates the correct and accurate identification of impurities in pharmaceutical products and intermediates
  5. Freeze drying ADCs: points to consider for industrial applications As antibody-drug conjugates gain momentum in the pharmaceutical industry, manufacturers are increasingly looking to implement safe and effective process trains to produce them. Lyophilisation experts at GEA Pharma & Healthcare assess some of the most critical challenges and how to overcome them

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