How self-replicating RNA can transform in vitro-transcribed drug development

In vitro-transcribed (IVT) ribonucleic acids (RNAs) are integral to next-generation nucleic acid-based drugs. The recent success of messenger RNA (mRNA)-based vaccines against COVID-19 created new opportunities to untangle their working mechanism, advantages and disadvantages. Kerstin Pohl, Senior Manager, Cell & Gene Therapy and Nucleic Acids, SCIEX, reports
Farmabios achieves cGMP approval for large-scale HPAPI and steroid production

Axplora company Farabios has announced the cGMP approval from the national public body regulating medicines for human use in Italy (AIFA) for the first line of its new production unit
Multiply Labs' robotic pharmaceutical manufacturing project reaches proof-of-concept

The consortium which contains Multiply Labs, Thermo Fisher, Cytiva, UCSF and Charles River has reached proof-of-concept on a robotic and automated cell manufacturing system
Poolbeg Pharma to use unique oral delivery platform for new condition

A strategic collaboration has been agreed with a biopharma to focus on the development of an optimised drug for a metabolic condition using Poolbeg’s licensed oral delivery technology
Clariant launches new range of excipients to improve stability and solubility of APIs

Clariant Health Care has expanded its range of functional excipients to solve active pharmaceutical ingredient (API) delivery & bioavailability challenges
Automation expert Hamilton expands to forge partnerships in pharma and life sciences

The expert in automation technology and analytical sensors has announced a significant expansion and enhancement of its Field Services division
EnginZyme produces key mRNA vaccine ingredient pseudouridine using biocatalysis

The Sweden-based deep-tech company whose cell-free biomanufacturing technology uses the power of enzymes to create sustainable products and processes for a variety of industries, has announced that it has patented a process to synthesise pseudouridine
Itema and Tofflon launch Tofflonit to serve European biopharma sector

Italy-based Itema and China-based Tofflon Science And Technology Group have launched the new joint venture for the production of industrial lyophilisers for the biopharmaceutical sector

Breaking News

Personalised and digitised: the future of pharma

Personalised and digitised: the future of pharma

Dr Kevin Robinson recently caught up with ChargePoint’s Ben Wylie and Cognizant’s Trevor Marshall to find out what trends and innovations the pharm...
AMSBIO highlights groundbreaking 2023 life science research

AMSBIO highlights groundbreaking 2023 life science research

In an informative new blog post, AMSBIO reflects on a selection of the groundbreaking life science and biomedical research undertaken by its custom...
EC appoints RISE Research Institutes as a reference laboratory for medical devices for in vitro diagnostics

EC appoints RISE Research Institutes as a reference laboratory for medical devices for in vitro diagnostics

RISE is one of two laboratories in Europe appointed to evaluate products for in vitro diagnostics to diagnose virus-borne upper respiratory tract i...
Getting personal: a patient-centred approach to rare disease drug development

Getting personal: a patient-centred approach to rare disease drug development

In this article, Nazim Kanji, Executive Director, Pediatric Services at Quotient Sciences, explores the challenges associated with developing formu...
Gyros Protein Technologies and Biotage partner to advance peptide purification efficiency

Gyros Protein Technologies and Biotage partner to advance peptide purification efficiency

Partnership complements Gyros’ PurePep EasyClean technology offering with an automated solution for advanced discovery process
Enhanced protection to manufacture highly potent pharmaceuticals introduced at NJ facility

Enhanced protection to manufacture highly potent pharmaceuticals introduced at NJ facility

Experic, a contract development and manufacturing organization (CDMO) and clinical trial supply services company serving the biopharmaceutical indu...
Driving peptide development and manufacturing

Driving peptide development and manufacturing

Peptides are revolutionising drug discovery and development. Sitting in size between the classic small molecule drugs (SMDs) and the newer generati...
How to proactively address EU HTAR implementation challenges before 2025

How to proactively address EU HTAR implementation challenges before 2025

Data landscape challenges within the European Union (EU) have historically been driven by the different laws, processes and regulatory standards of...
Aptar Pharma continues global expansion with new Mumbai site

Aptar Pharma continues global expansion with new Mumbai site

Aptar Mumbai to increase manufacturing capabilities in growing South East Asia market
Innovent Biologics and Synaffix expand ADC collaboration

Innovent Biologics and Synaffix expand ADC collaboration

New deal builds on encouraging preliminary clinical data from the Phase I study of the first antibody-drug conjugate (ADC) developed under the agre...
The roadmap to success in the cannabinoid drug development journey

The roadmap to success in the cannabinoid drug development journey

The key to success in the development and registration of cannabinoid-based medicines hinges on choosing a GMP-certified high-purity active ingredi...
Adding more to the cell and gene therapy playbook

Adding more to the cell and gene therapy playbook

With notable advances in various forms of administration, including making the use of viral vectors safer, non-viral delivery with lipid nanopartic...
TeraPore launches IsoBlock VF viral filtration products with proprietary membrane technology

TeraPore launches IsoBlock VF viral filtration products with proprietary membrane technology

TeraPore Technologies, an innovator in nanofiltration membranes, has commercially launched the flagship IsoBlock VF product line for parvovirus rem...
Diagnosing hormone-based disorders using saliva

Diagnosing hormone-based disorders using saliva

Diagnosing hormone-based disorders using saliva samples dates back to the 1980s; however, it’s only the sensitivity improvements that have occurred...
Abzena Partners with ProteoNic to offer enhanced CHO cell line platform for complex biologics

Abzena Partners with ProteoNic to offer enhanced CHO cell line platform for complex biologics

Premium vector technology will improve the production of high-yielding mammalian cell lines
The right validation model: practical considerations and applications

The right validation model: practical considerations and applications

It is widely accepted that validation in the life sciences industry follows a lifecycle model (1,2). What is not always clear is the specific model...

In Brief

Novel high speed rack reader promotes accuracy and compatibility

Optimised degassers for nanofluidic systems

Biotium launches new line of extensively validated primary antibody conjugates for flow cytometry

Enteric delivery of my API: how to make it right?

Spatial biology multi-omics profiling tools

BICO company Biosero signs agreement to develop laboratory automation solutions to a value of 28 MUSD

Nordic-Irish Process Chemistry Forum 2023

Macsa ID has its eye on the contact lens market

Sixth release of Matrix Gemini LIMS highlights a year of rapid enhancements

Vitafoods Europe

CPHI Barcelona Snapshot: Catalent

Ariceum received US and Canadian patents for its Gallium-68 radiopharmaceutical production kit

X-Chem announces achievement of collaboration milestone

TurboFil introduces fully automatic version of popular syringe filling system

INEOS Styrolution’s sustainable NAS ECO selected cuts CO2 emissions by 93% in healthcare application

908 Devices launches MAVERICK for real-time in-line monitoring of multiple bioprocess parameters

CPHI Barcelona Snapshot: Purolite

Almirall, Barcelona Supercomputing Center and Nostrum Biodiscovery collaborate to find AI-based therapies

Anton Paar Launches TAG 500/300 Flash Point Tester Series for Precision Testing

PSG Biotech launches new Quattroflow QB2-SD Single-Use Micropump

ROSS Mixers offers Trial Rental Program for R&D scale equipment

CPHI Barcelona Snapshot: CordenPharma

Most Popular

  1. Driving peptide development and manufacturing
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  3. New state-of-the-art genomic services facility opening in the UK
  4. Hello SDAX! SCHOTT Pharma reaches next milestone as a publicly listed company
  5. Vetter joins Science Based Targets initiative

Inspiration and Learning

Manufacturing Chemist Stand Side with IMA S.p.A
Manufacturing Chemist Stand Side with IMA S.p.A
Manufacturing Chemist Stand Side with ACG
Manufacturing Chemist Stand Side with ACG
Manufacturing Chemist Stand Side with Lonza
Manufacturing Chemist Stand Side with Lonza
Manufacturing Chemist Stand Side with Piramal Pharma Solutions
Manufacturing Chemist Stand Side with Piramal Pharma Solutions
Manufacturing Chemist Stand Side with Syntegon
Manufacturing Chemist Stand Side with Syntegon
Manufacturing Chemist Stand Side with C2 Pharma
Manufacturing Chemist Stand Side with C2 Pharma
Manufacturing Chemist Stand Side with Almac
Manufacturing Chemist Stand Side with Almac
Enteric delivery of my API: how to make it right?
Enteric delivery of my API: how to make it right?
Find the right diaphragm valve for pharmaceutical applications - DOWNLOAD THE NEW REPORT
Find the right diaphragm valve for pharmaceutical applications - DOWNLOAD THE NEW REPORT
Cleaning validation and verification in a high potent granulation suite
Cleaning validation and verification in a high potent granulation suite

Careers

Jose Ibietatorremendia to join Veranova as SVP, General Counsel and Secretary
Transgene strengthens its leadership team to accelerate its growth strategy
Dr Steven Chatfield, an advisor to the vaccines task force during the COVID pandemic, joins Stablepharma
Versameb names Dr Alexandre LeBeaut as Chair of the Board of Directors
Kling Bio appointment of Dr Stefano Gullà as Chief Scientific Officer
Dr Günter Stempfer appointed Site Head Laupheim for Rentschler Biopharma
Zenas BioPharma strengthens executive leadership team
Poolbeg Pharma PLC announces directorate change
AC Immune strengthens management, appoints Madiha Derouazi as CSO and Christopher Roberts as CFO
Broken String Biosciences appoints Gavin Burns as Vice President of Quality and Operations

Reports

Getting personal: a patient-centred approach to rare disease drug development
Getting personal: a patient-centred approach to rare disease drug development
Driving peptide development and manufacturing
Driving peptide development and manufacturing
The roadmap to success in the cannabinoid drug development journey
The roadmap to success in the cannabinoid drug development journey
Diagnosing hormone-based disorders using saliva
Diagnosing hormone-based disorders using saliva
The right validation model: practical considerations and applications
The right validation model: practical considerations and applications
Analytical method development in a high potent facility
Analytical method development in a high potent facility
Investing in a manufacturing infrastructure to harness tumour-infiltrating lymphocytes (TILs) for cancer treatment
Investing in a manufacturing infrastructure to harness tumour-infiltrating lymphocytes (TILs) for cancer treatment
Simplifying technology transfer to get drugs to market faster
Simplifying technology transfer to get drugs to market faster
Bio-Courier: a new delivery technology to increase the global accessibility of RNA therapeutics
Bio-Courier: a new delivery technology to increase the global accessibility of RNA therapeutics
What’s in a partner? The essential facets of a strong biopharma collaboration
What’s in a partner? The essential facets of a strong biopharma collaboration