Sartorius Stedim Biotech adds new crossflow filtration system for process development to portfolio


Suitable for scaling studies and low volume ultra- and diafiltration operations

Sartorius Stedim Biotech (SSB) has added Sartoflow Smart to its portfolio, a benchtop crossflow system for optimised ultra- and diafiltration applications.

SSB says Sartoflow Smart can be used in many downstream processes, such as purification of vaccines, monoclonal antibodies and recombinant proteins. The system is suitable for flexible use in laboratories for process development and clinical trials as well as for cGMP environments.

The system is equipped with a low shear four-piston membrane pump that enables highest product yields to be achieved. In addition, the pump provides a wide range of flow rates allowing users to choose between membrane surface areas from 50cm2 to 0.14m2.

The crossflow system is supplied with SSB’s intuitive and easy to use DCU-4 control unit, which, when combined with the company’s BioPAT SCADA, MFCS-4 software, provides data logging and export. Its touchscreen offers instant access to all critical process parameters and displays control and alarm functions. A logbook function stores alarms, set points and user logs.

The Sartoflow family of crossflow systems shares operation design with a 7in touchscreen that supports the operator with interactive prompts for easy guidance through the entire process. Users can select predefined parameters to automatically run sequences for concentration, diafiltration, rinsing, filling, draining, flushing steps and tare functions.

An optional peristaltic diafiltration pump is available to load product or buffer as a discrete process step. Furthermore, several options are available to customise the system according to specific requirements. For example, a conductivity, pH or temperature probe can be installed in the recirculation vessel.

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The system can also be upgraded in the case of changing process requirements.