US researchers work on novel polymers for drug delivery

By combining Malvern Instruments’ Viscotek GPC and Zetasizer Nano

Multidetector GPC system from Malvern Instruments

Researchers at the Department of Bioengineering at the University of Pittsburgh are using Malvern Instruments’ Viscotek gel permeation chromatography (GPC) system to characterise polymer molecular weight, prior to applying the Zetasizer Nano for zeta potential measurements to study inter-molecular interactions.

Hunghao Chu, a graduate student in the Department of Bioengineering in Pittsburgh University’s Swanson School of Engineering, synthesises new polymers to control the release of growth factors that regulate cell activity and body function. These molecular platforms are expected to have multiple applications in drug delivery.

‘GPC is fundamental to our research,’ said Chu. ‘We have to fully understand our new polymers and GPC delivers absolute molecular weight measurement. We also need to know the polydispersity index of our samples to understand polymer homogeneity. When publishing data in peer reviewed journals it is very important to have confidence in results and to be able to validate them.’

The Viscotek line of instruments offers a complete, temperature controlled, multidetector GPC system suitable for all macromolecular applications.

The Zetasizer series measures particle and molecular size from below a nanometre to several microns, zeta potential, electrophoretic mobility, and molecular weight. In addition the system can be connected to a GPC system to enable it to be used as a chromatography detector.

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