3M’s Purification Division has enhanced its encapsulated single-use depth filtration range by releasing new scaling tools.
The Zeta Plus scale-up capsule filters are said to be easy to use and allow predictable performance when scaling from laboratory fermentations during process development to commercial biomanufacturing and purification.
The three new Zeta Plus capsule filters – E0170, E0340 and E1020 – have a filtration surface area of 170cm2, 340cm2, and 1020cm2 respectively. They complete 3M’s disposable filtration range, which now extends from the 25cm2 BC25 model to units of 11.2m2 or 17.5m2, configured using capsules with a positive cam locking mechanism and manifolds in a range of holders. For applications requiring an even larger filtration area, the Zeta Plus encapsulated system multi-round holder combines multiple 11.2/17.5m2 filter carousels.
‘Our new Zeta Plus encapsulated devices allow customers greater flexibility when scaling processes from laboratory, through small scale Good Manufacturing Practice (GMP) and ultimately commercial manufacture. All media and flow paths are identical in the devices to facilitate linear scaling and robust, reproducible purification data,’ said Lynne Deakin, field applications specialist at 3M’s Purification Division.
The Zeta Plus capsule filters can be used in parallel or in series, and provide the flexibility to use different filter media at the same time.
