Pertuzumab is a targeted cancer drug that binds to the HER2 protein, which is overexpressed in HER2-positive cancers, preventing cell growth and proliferation
Bio-Rad Laboratories, a supplier of research and clinical diagnostic products, has introduced four inhibitory antibodies highly specific to pertuzumab (Perjeta). These ready-made antibodies inhibit the binding of the drug to its target, human epidermal growth factor 2 (HER2), and are designed to help researchers to develop selective and sensitive assays for bioanalysis and drug monitoring of pertuzumab and its biosimilars.
Pertuzumab is a targeted cancer drug that binds to the HER2 protein, which is overexpressed in HER2-positive cancers, preventing cell growth and proliferation. The range of anti-pertuzumab antibodies includes monovalent Fab format antibodies suitable for the development of a pharmacokinetic bridging ELISA to measure free drug, as well as fully human IgG1 antibodies with varying levels of affinity, which can be used as a surrogate positive control or reference standard in an anti-drug antibody assay.
“We’re continuously introducing new ranges of recombinant, monoclonal anti-idiotypic antibodies to support researchers in developing robust methods that deliver reproducible and translatable results,” said Amanda Turner, Bio-Rad Product Manager, Life Science Group. “These sequence-defined reagents are well-characterised and non-animal-derived to ensure batch-to batch consistency and help reduce the use of animals in scientific research.”
The antibodies are generated using the human combinatorial antibody libraries (HuCAL) and CysDisplay, a proprietary method of phage display, along with guided selection methods to obtain targeted reagents. The recombinant production method is used to ensure consistent and secure supply.
The anti-pertuzumab antibodies are approved for in vitro research purposes and for commercial services providing in vitro testing to support preclinical and clinical drug development.