BioreclamationIVT and Qualyst partner to market Transporter-Certified hepatocytes

Published: 23-Jun-2017

BioreclamationIVT, a leading provider of biospecimens and related services, is partnering with Qualyst Transporter Solutions to market Transporter-Certified cryopreserved human hepatocytes

Transporter Certified is an industry standard that ensures hepatocytes have physiologic transporter function, metabolic competence and appropriate regulatory pathways under conditions Qualyst has defined.

In sandwich culture, the intracellular concentrations in Transporter Certified hepatocytes reflect physiologic conditions because the hepatocytes express functioning uptake and efflux transporters and develop bile pockets similar to bile canaliculi.

Qualyst’s patented B-CLEAR Technology is used to evaluate hepatocyte lots and qualify them as Transporter Certified. B-CLEAR Technology allows quantitation of biliary efflux in an in vitro model.

BioreclamationIVT is a leader in producing high quality hepatocyte products that enable scientists and biomedical researchers to better understand the pharmacokinetics and drug metabolism of newly discovered compounds and the effects on disease processes.

Specifically, Transporter Certified hepatocytes can be used for transporter studies, quantitation of basolateral versus biliary efflux, drug interaction experiments, intracellular concentration determination, induction, metabolism, hepatotoxicity or any experiment when transporters and in vivo correlation are important.

“BioreclamationIVT’s top priority is providing high quality biological products to meet our clients’ research needs,” said BioreclamationIVT’s Chief Scientific Officer Dr Chris Hansis.

“Through our new partnership with Qualyst, we can assure our customers that the hepatocyte lots we supply have transporter uptake and efflux levels that are physiologically relevant under defined culture conditions.”

“We are delighted to welcome BioreclamationIVT as a partner for Transporter Certified hepatocytes,” said Qualyst Chief Executive Officer Dr Chris Black.

“These hepatocytes perform at the highest level because we uniquely characterise and certify their transporter and bile acid function. In other words, researchers can use these cells with confidence in their experiments and know that a third party has evaluated their performance.”

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