Codexis and MSD sign multi-year extension of enzyme supply contract

Agreement covers enzyme used in manufacture of sitagliptin

Leading biocatalyst developer Codexis has signed an agreement extension with Merck Sharp & Dohme , known as MSD outside the US and Canada, to license and supply a proprietary enzyme used in the manufacturing process for sitagliptin, the active pharmaceutical ingredient in Merck’s Januvia and one of the active ingredients in Merck’s Janumet.

Under a research and development agreement, Codexis and Merck used the CodeEvolver protein engineering platform technology to develop a customised enzyme to serve as a biocatalyst in the sitagliptin process. The resulting enzyme streamlined the manufacturing process and increased production yield, while reducing costs and waste. In 2012 Codexis and Merck entered into a supply agreement for the enzyme.

'The extension of this contract, coming on the heels of our licensing agreement for the CodeEvolver technology, is yet another vote of confidence in our protein engineering technology,' said Codexis President and CEO John Nicols. 'We are proud to continue our long term collaboration with Merck.'

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