Domain Therapeutics receives $125m to assign its intellectual property

Domain Therapeutics to receive up to $125 million for assignment of its intellectual property covering the Foliglurax mGluR4 PAM series discovered by a French biotech

Domain Therapeutics is pleased to congratulate its partner company Prexton Therapeutics on its acquisition by H. Lundbeck. Prexton’s drug candidate, Foliglurax, is currently in clinical Phase II for symptomatic treatment of OFF-time and dyskinesia (involuntary muscle movements) in Parkinson’s disease.

The series of compounds, from which Foliglurax originated, was initially discovered by Domain Therapeutics, licensed to Prexton in 2013 and assigned as part of the acquisition by Lundbeck.

Foliglurax itself was identified by Domain who worked closely with Prexton to advance the programme from discovery to development. This first-in-class molecule is the only metabotropic glutamate receptor 4 Positive Allosteric Modulator (mGluR4 PAM) to have reached the clinic.

As a Prexton shareholder and patent assignor, Domain will receive up to $125 million depending on the successful outcome of certain undisclosed milestones.

“This transaction, one of the more significant recent trade sales of a European private biotechnology company, validates Domain’s strategy of partnering the development of its drug candidates through asset-centric companies,” said Pascal Neuville, CEO of Domain Therapeutics.

“The team at Prexton was excellent in rapidly moving Foliglurax through preclinical and early clinical stages in order to make this promising treatment available to the Parkinson’s disease patient population.”

“Our fruitful partnership with Domain resulted in the selection of Foliglurax that we successfully developed through these early development stages,” said Francois Conquet, Founder and CEO of Prexton.

“This collaboration is an example of complementarity between partners to jointly develop a valuable asset for a major indication.”

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