Malvern presents in-line particle sizing for high shear granulation

Published: 30-Apr-2010

Particle velocimetry is ideal for monitoring processes such as granulation, spray drying, fluidised bed and particle size reduction

At the Advances in Process Analytics and Control Technology 2010 Conference (APACT 10; 28-30 April 2010, Manchester, UK), Malvern Instruments process systems specialist Jarvis Jeejing gave a presentation of in-line particle size analysis for high shear granulation processes. He introduced the technique of particle velocimetry for in-line particle size measurement, focusing on its application to the control and optimisation of high shear granulation processes within the pharmaceutical industry. Mr Jeejing’s presentation formed part of a session on 29 April dedicated to industrial applications of process analysis. Malvern also participated in the associated trade exhibition.

Particle velocimetry, exemplified in the Parsum inline particle probe (IPP70) from Malvern Instruments, is a technique that is suitable for measuring particles in the size range 50 to 6000µm, travelling at velocities of between 0.01 and 50m/s. This makes it ideal for monitoring processes such as granulation, spray drying, fluidised bed and particle size reduction.

The importance of granulation in pharmaceutical manufacturing is well established, where it is used widely to improve the flow properties and consistency of tableting blends, as well as for other properties. High shear (or wet) granulation delivers high throughput and dense, uniform, dust-free granules, but its optimisation can be challenging. Continuous monitoring offers a valuable approach.

www.malvern.com/process

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