QPhos is a reportedly promising ligand in metal-catalysed cross-coupling reactions, fundamental to construct carbon-based bonds featured in most drug scaffolds
Sinocompound Catalysts, a global provider of advanced homogeneous catalysts and ligands, has announced production of the phosphine-based QPhos ligand in kilogram quantities for commercial use. The company can now offer QPhos-based catalysts for, screening and process development programs to optimise and streamline the product development phase.
QPhos is a reportedly promising ligand in metal-catalysed cross-coupling reactions, fundamental to construct carbon-based bonds featured in most drug scaffolds. Until now, however, it has not been readily available in commercial quantities, hindering its adoption in process development and scale-up programs.
“There’s an enormous amount of untapped potential in ligands that scientists simply can’t access on a large scale, so they discount them from their screening programs,” said Dr Carin Seechurn, Associate Director – Technology Solutions, Sinocompound. “Our capability to scale-up the QPhos ligand represents a significant milestone in improving ligand accessibility for researchers. As we continue to expand our manufacturing processes thanks to our new plant in Tongling, we’re excited to provide more overlooked ligands and products commercially.”
QPhos is a robust dialkylarylphosphine ligand developed by Professor John Hartwig for metal-catalysed cross-coupling reactions. Bulky and electron-rich, its claimed to perform excellently in many transformations including α-arylation of carbonyl compounds and late-stage C-C bond formation.