The vapour permeability of transdermal patches

The vapour permeability or porosity of transdermal patches is the critical factor in drug delivery to the patient, with different layers requiring different permeabilities for different vapours

Versaperm is a world technology leader in vapour permeability measurements and has introduced a new instrument, which can determine the precise permeability of each layer or aspect of the transdermal patch.

Measuring the vapour permeability of the different vapours, materials and laminate structures in patches allows manufacturers to develop and quality control new and enhanced products, enabling them to optimise dose delivery rates for individual medication.

Versaperm's equipment is fast, simple to use, accurate and can measure the permeability of each layer individually, or complex multi-layer structures as well as the product's packaging.

The system measures to a repeatable accuracy in the in parts per million (PPM) range, with PPB range for some materials, this is crucial for both new product development and quality control.

Elements controlled by the transdermal patch's vapour permeabilities include its drug release rate, which is either controlled by a membrane or by the adhesive.

Additionally, the permeability of the patch's backing layers protects the medication from contamination during patient use and permeation enhancers are sometimes used to increase the rate of delivery drug.

Lastly the product's packaging's permeability limits contamination during storage.

As well as developing and manufacturing the equipment, Versaperm offers a technical consultancy and a quick-turn-around laboratory testing service.

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