The ActiPix Dissolution Imager from UK-based Paraytec offers pharmaceutical companies an affordable dissolution imaging capability that does not require expert operation.
To date, only high cost, complex techniques such as Terahertz Spectroscopic Imaging and Magnetic Resonance Imaging (MRI) have been able to produce the data to enable formulation scientists to understand complex pharmaceutical drug release processes.
York-based Paraytec says the ActiPix Dissolution Imager overcomes these limitations.
Using a specially designed tablet holder, controlled release pharmaceuticals can be studied using Paraytec's ActiPix D-100 UV area imager. The holder is placed inside the ActiPix D-100, which enables realtime recording and review of data. When liquid flows over the surface of the formulation, release of the active ingredient can be quantitatively monitored directly at the tablet surface.
The ActiPix D100 contains a high-resolution 1,280x1,024 Active Pixel sensor. Compact in design, it consists of a control box connected via fibre-optic and communications cables to a remote sensor head. This sensor head holds easily exchangeable, application-specific cartridges used with powerful software, enabling the end-user to switch between applications.
The detector can be used as a 'plug and play' accessory linked in-line to single or multiple peripheral devices, such as syringe pumps and existing CE or nanoLC instrumentation. These can be further coupled to other devices such as mass spectrometers to give a greater depth of information. Detection is performed at a selected wavelength by means of interchangeable filters. The detector wavelength range is 190 to 1100nm.
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