At-line monitoring of antibody production
Protein ScreenTape system delivers yield, purity and molecular weight data in minutes
Laboratory automation specialist Lab901 says its Protein ScreenTape can deliver, for the first time, practical at-line monitoring of monoclonal antibody production. This has previously been impractical due to the high cost per test point and long analysis time, the Edinburgh firm says.
With its rapid staining protocol and automated sample handling, electrophoresis and data presentation, the Protein ScreenTape system can deliver information on yield, purity and molecular weight within a few minutes. Samples can be analysed direct from the bioreactor without needing to purify or filter the media. Analysis of media containing high levels of serum is also possible.
‘It is now possible to assess antibody production by SDS-PAGE on a day-by-day, or even hour-by-hour basis, making this information invaluable not only for process optimisation, but also for batch monitoring,’ said Adam Inche, Lab901 application scientist.
‘Using this data our clients will be able to make more informed decisions on when to harvest their bioreaction batch, thereby saving them time and money.’
Lab901 has been selling its D800 and DS12 DNA ScreenTape products into the PCR diagnostics market for the last 18 months and has shipped more than 70 systems globally.
ScreenTape R6K for RNA QC is the latest product to be developed and manufactured at Lab901’s production facility in Loanhead, Edinburgh.