Corgentech licenses novel peptide delivery system from Cyclacel

Published: 28-Sep-2004

US biotechnology company Corgentech has entered into an exclusive license with UK-based Cyclacel Group to utilise Cyclacel's Penetratin Endonuclear Delivery System for use with Corgentech's transcription factor decoy (TF Decoy) technology platform.


US biotechnology company Corgentech has entered into an exclusive license with UK-based Cyclacel Group to utilise Cyclacel's Penetratin Endonuclear Delivery System for use with Corgentech's transcription factor decoy (TF Decoy) technology platform.

Corgentech's TF Decoy technology is a new class of therapeutics that blocks the activity of multiple genes linked to a disease. The company has developed a proprietary method using controlled uniform pressure for efficient delivery of TF Decoys into cells and tissues. Its lead product, edifoligide (E2F Decoy), is in Phase III clinical trials for the prevention of bypass vein graft failure.

Penetratin enables systemic cellular delivery by chemically linking to TF Decoys, and actively trans-porting the TF Decoy therapy into cells. Corgentech will have responsibility for the development and commercialisation of TF Decoys combined with a Penetratin peptide. Cyclacel will receive an up-front payment, milestone payments, and royalties if licensed products are commercialised. No further financial terms were disclosed.

'Penetratin peptides represent an exciting and versatile additional delivery technology that will help us to expand the number of diseases addressable by our drugs,' said John McLaughlin, Corgentech's president and chief executive officer.

  

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