CSC gains distribution rights for ALOXI

Published: 24-Mar-2005

Helsinn Healthcare, a Swiss pharmaceutical group, and CSC, a pharmaceutical company based in Austria, have signed an agreement granting CSC the exclusive license and distribution rights for ALOXI (Palonosetron hydrochloride) in Austria and other countries in central and eastern Europe.


Helsinn Healthcare, a Swiss pharmaceutical group, and CSC, a pharmaceutical company based in Austria, have signed an agreement granting CSC the exclusive license and distribution rights for ALOXI (Palonosetron hydrochloride) in Austria and other countries in central and eastern Europe.

ALOXI is a strong and long acting antiemetic belonging to the second generation of serotonin (5-HT3) antagonists, the leading class for the prevention of Chemotherapy-Induced Nausea and Vomiting (CINV).

Last December the CHMP recommended ALOXI approval in Europe for the prevention of acute nausea and vomiting associated with highly emetogenic cancer chemotherapy; and of nausea and vomiting associated with moderately emetogenic cancer chemotherapy. In the US, where the product is currently commercialized and over a million uses have been successfully completed, National Comprehensive Cancer Network (NCCN) guidelines, published in 2004, indicated ALOXI as the treatment of choice for CINV.

CINV is estimated to affect 85% of cancer patients undergoing chemotherapy and can result in a delay or discontinuation of chemotherapy treatments. Successful prevention of these symptoms would allow patients to tolerate anti-cancer treatment to a greater extent, thereby improving their chances of successfully completing treatment, and giving them a better quality of life.

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