Domantis in therapeutic alliance with Bristol-Myers Squibb

Published: 7-Dec-2005

Human Domain Antibody (dAb) therapeutics company Domantis has entered into a multi-target discovery collaboration with Bristol-Myers Squibb to develop dAb therapeutics for uses in the fields of immunology and oncology.


Human Domain Antibody (dAb) therapeutics company Domantis has entered into a multi-target discovery collaboration with Bristol-Myers Squibb to develop dAb therapeutics for uses in the fields of immunology and oncology.

The collaborators aim to discover a range of novel dAbs to address therapeutic targets involved in T-cell co-stimulation (part of the human immune response), some of which may not be amenable to targeting with conventional antibody approaches.

Under the terms of the agreement, Domantis will receive US$9.2m in upfront and guaranteed research payments. It will also be eligible for pre-clinical and clinical milestone payments of up to $20m per product, as well as royalties on product sales. Domantis will contribute two of its existing dAb therapeutic programmes and will create a range of new dAbs to pre-determined targets, with B-MS having the exclusive right to develop and commercialise dAb therapeutics discovered during the collaboration.

'We believe this alliance could produce several novel dAb therapeutics for the treatment of important diseases such as rheumatoid arthritis, transplant rejection and many others in the fields of both immunology and oncology,' said Domantis ceo Robert Connelly.

  

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