Merck Millipore, the life science division of Merck headquartered in Billerica, Massachusetts in the US, has launched the Cellvento CHO-200 chemically defined cell culture medium, a product of non-animal origin that it says ‘delivers robust cell growth and consistent high performance’.
Accompanied by complementary Cellvento Feed products, the new medium is for fed-batch processes using CHO-S cell types expressing monoclonal antibodies.
Merck Millipore says Cellvento CHO-200 medium and its corresponding feeds do not contain hydrolysates or components of unknown composition, resulting in very good lot-to-lot consistency.
The formulation supports high cell density growth and extended culture duration as well as long duration of high cell viability, the firm says.
This facilitates the production of high protein titres and results in strong productivity and product quality.
Merck Millipore produces Cellvento CHO-200 medium and Cellvento Feeds in dry powder form at its cGMP facility, using fully traceable raw materials sourced from qualified suppliers, leading to reliable homogeneity that allows for effective powder dissolution and uniform component distribution. A liquid version of Cellvento CHO-200 medium will be introduced this autumn.
Antoine Heron, Merck Millipore’s Head of Biopharm Materials and Technologies, said the new product ‘expands our existing CHO medium offerings, allowing us to fully support our customers as they switch to the production mode of operation’.
