Sartopore Platinum introduces sterilising-grade filters

Published: 25-Jun-2012

Modified membrane increases product yield and improves manufacturing workflows

Sartorius Stedim Biotech (SSB), an international pharma and biotech supplier, says its Sartopore Platinum family of sterilising-grade filters sets new standards in sterile filtration and expands its filter portfolio.

The surface of the Sartopore Platinum polyethersulfone filter membrane has been modified using a hydrophilic and highly thermostable polymer. SSB says this gives the membrane excellent wetting properties and minimises its protein binding. Fewer than five litres of WFI (Water for Injection) are needed to wet a 10in Sartopore Platinum cartridge for subsequent integrity testing.

The membrane’s minimised protein binding considerably increases product yield, thus augmenting the efficiency of manufacturing processes.

The new filter cartridges can be dry steam sterilised in the forward or reverse direction, without altering the properties of their membrane. They can be used in the entire pH range from 1–14 and therefore for nearly any filtration application in biopharmaceutical manufacturing.

The membrane of the Sartopore Platinum filter cartridges has been pleated using SSB’s proprietary TwinPleat process. The alternating long and short pleats of the membrane increase the filter area of a 10in cartridge by more than 60%. This geometry ensures that liquids flow through the entire filter area so that the filtration capacity of the cartridge is used to the fullest extent.

The cartridges are available in a choice of sizes and constructions ranging from lab to production scale.

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