PL's new scattering detector

Published: 1-Feb-2003


LC-MS is an analytical tool to identify and quantify samples for a wide range of applications. Some compounds with little or no UV chromophore can benefit from enhanced LC-MS capability by interfacing with the high sensitivity PL-ELS 1000 evaporative light scattering detector.

The PL-ELS 1000 from Polymer Laboratories can detect the presence of a compound not clearly identified by UV, and having detected the compound by ELS, the LC-MS can provide more detailed information. The PL-ELS 1000 can also provide concentrations and intelligence on compounds which don't ionise on the LC-MS. These benefits are useful for combichem libraries.

The PL-ELS 1000 exhibits low band broadening which, together with a noise free baseline, results in high resolution separations even with rapid gradient elution.

The PL-ELS 1000 and LC-MS systems have similar chromatographic requirements, that the eluent must be volatile. The PL-ELS 1000 is compatible with and complementary to LC-MS systems. For maximum flexibility and optimum choice, the evaporative light scattering detector can be used alone or as one of several detectors. It can be situated as the last detector inline, or the flow can be split, part to the PL-ELS 1000 and part to other detectors. The design of the detector ensures a controllable, stable split ratio throughout.

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