With more potent drugs gaining market approval, Michelle Frisch of Powder Systems Ltd (PSL) looks at the issues of containment when milling and offers some solutions.
Milling any compound is a challenge, but having to mill high potent or cytotoxic materials creates more of a problem. When milling a compound of any type, there is never a common mill that is used to gain the correct particle size: not only do manufacturers have to mill different compounds, they also have to use multiple types of milling equipment.
Some milling equipment is used very infrequently but still requires the complexity of applying high containment. Seeking to contain each type of mill, however, could run up costs well into millions of dollars. So to provide high containment for milling processes, companies should first identify what mills are used and how often. Quantities of compounds and container sizes also need to be evaluated. This then becomes the directive on what approach a company needs to take to develop a solution.
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