QuadraPure scavenger resins now in cartridge format
Catalyst technologies company Reaxa has made its QuadraPure scavenger resins for pharma process clean-up of precious metals available in a ready-to-use cartridge format. Reaxa has been working on product development with Clear Edge - through its Central Innovation Department and Madison Filter business unit - since mid-2005.
Catalyst technologies company Reaxa has made its QuadraPure scavenger resins for pharma process clean-up of precious metals available in a ready-to-use cartridge format. Reaxa has been working on product development with Clear Edge - through its Central Innovation Department and Madison Filter business unit - since mid-2005.
Pre-loaded QuadraPure/Clear Edge cartridges are said to achieve target toxic metal levels (<5ppm) on a single pass with less than 1% loss of product. This compares with typically reported 10-15% loss of product using traditional carbon clean-up.
Reaxa has a range of 10 macroporous and microporous QuadraPure metal scavenging resins as well as a new QuadraSil range of four silica-based metal scavengers.
The company sees a rapidly developing role for cartridge-based precious metal clean-up and purification in pharma production. In-line pharma process systems are increasingly seen as key to gaining the benefits of process intensification via flow technologies.
Two sizes of Reaxa/Clear Edge pre-loaded cartridge units are in development, with the smaller units already available for use in pilot plant/early phase applications. Compatible with Miniline filter vessels, these QuadraPure scavenger cartridges are ideal for process development batches through to pilot plant/early phase applications.
Production scale applications will be catered for by a larger QuadraPure scavenger cartridge, compatible with standard filter housing units. Both types are manufactured from virgin food grade PTFE and will be supplied with full Regulatory Support Files to assist in cGMP compliance.
Additional benefits of cartridge filtration include a large reduction in solvent usage (through avoidance of multiple recrystallisations and solvent/aqueous extractions) and a major reduction in metal contaminated waste - all of which is concentrated on the resin and retained in the cartridge. The plug-and-play cartridges obviate any handling of loose resin beads or fibres, simplifying reactor validation and compliance with GMP protocols.
'Cartridge-format scavenging promises to bring a step change in process re-engineering,' said Reaxa ceo Dr Pete Jackson. 'They play a major role in securing performance, cost and environmental compliance targets in the next generation of high-performance production systems.'