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Optical oxygen systems with ISM – a powerful combination

Optical oxygen systems with ISM – a powerful combination

Open the way for enhanced process control in biotech applications
New experimental techniques for organic synthesis

New experimental techniques for organic synthesis

Chemical synthesis beyond the round bottom flask - a review of modern technologies
Choosing the optimum flowmeter

Choosing the optimum flowmeter

Choosing the right flowmeter from the dozens of types available is difficult. Paul Trevitt, of Burkert UK, provides a few insights
Customised valve solutions revolutionise steam sterilisation

Customised valve solutions revolutionise steam sterilisation

Steam sterilisation of medical instruments requires a total evacuation of air from the chamber. Bürkert has developed a compact system solution based on an innovative multi-functional block design
Challenges of modern distribution

Challenges of modern distribution

Distributors of chemicals are having to take increasing responsibility for areas such as supply chain security, quality of materials, ethical sourcing of products and keeping both themselves and their customer up to date with the latest regulations, including REACH and the recent Classification Labelling and Packaging legislation
Production of pharmaceutical compounds through microbial fermentation

Production of pharmaceutical compounds through microbial fermentation

Most people’s experience of fermentation will be through its most famous and popular use – the brewing of beer
Filtration trials with SAFC EX-CELL CD Hydrolysate Fusion

Filtration trials with SAFC EX-CELL CD Hydrolysate Fusion

Following the launch of the EX-CELL CD Hydrolysate Fusion – the first fully chemically defined media supplement of its kind in the industry – SAFC conducted a study with partner company Sartorius Stedim Biotech to determine the throughput and biological activity of filters
Fermentation technology: cooking up new therapeutics

Fermentation technology: cooking up new therapeutics

With a new state-of-the-art, cGMP fermentation facility in Jerusalem, SAFC is looking at new applications for what is viewed by many as a traditional technology. These applications include the synthesis of High Potency Active Pharmaceutical Ingredients (HPAPIs) and therapeutic drugs
Trends in the manufacturing of viral gene therapeutics and next generation vaccines

Trends in the manufacturing of viral gene therapeutics and next generation vaccines

Gene therapy is still an experimental technology, but the dangers are now much better understood, according to Jeff Strobel, site director, SAFC Carlsbad, CA
Handling protocols: key consideration in HPAPI market

Handling protocols: key consideration in HPAPI market

Over the past 10 years, the manufacture of highly potent APIs has become increasingly attractive to contract manufacturers, says Trevor Calkins, director of process development, SAFC
Linking biological molecules to highly potent APIs

Linking biological molecules to highly potent APIs

Antibody-drug conjugate technology is the ‘smart bomb’ in the arsenal of weapons used to target cancer cells, says Cynthia Wooge, SAFC process development manager
IR spectroscopy on the move

IR spectroscopy on the move

Perkin Elmer\'s latest spectrometer, Spectrum Two, brings spectroscopy to the non-specialist
Temperature tracking

Temperature tracking

As clinical trial sites move to distant geographic areas and more biologics are involved, temperature monitoring of drug shipments becomes a growing need. Almac has responded with a system it believes will transform temperature monitoring for clinical trials
Case study: Five years of trouble-free manufacturing for large pharma company

Case study: Five years of trouble-free manufacturing for large pharma company

Alkermes, through the merger with Elan Drug Technologies, to become Alkermes plc, has been developing and manufacturing commercial scale solid oral dosage products for more than 40 years. This case study demonstrates a large pharmaceutical contract manufacturing engagement in which there has been five years trouble-free supply with OTIF (On-Time-In-Full) consistently >95%.<br> Process and product improvement initiatives were also delivered, which enabled significant capacity and yield improvements. These improvements resulted in significant cost savings for our partner.

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