Characterising nitrosamine impurities in sartan compounds with an Agilent GC/TQ system with hydrogen carrier gas

Published: 29-Jan-2025
Regulatory Research & Development Analysis

Exploring the analysis of nitrosamine contamination in sartan drugs using Agilent's innovative triple quadrupole (TQ) GC/MS system with hydrogen carrier gas

Nitrosamine impurities in pharmaceutical compounds are a critical concern due to their potential carcinogenicity. This application note presents an advanced method for the efficient detection and quantification of nitrosamine impurities in sartan drugs, leveraging an Agilent GC/TQ system with hydrogen as the carrier gas. The study highlights the efficacy of hydrogen as a sustainable alternative to helium, demonstrating comparable performance while mitigating challenges associated with helium scarcity.

Read the full application note here.

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