Characterising nitrosamine impurities in sartan compounds with an Agilent GC/TQ system with hydrogen carrier gas

Published: 29-Jan-2025
Regulatory Research & Development Analysis

Exploring the analysis of nitrosamine contamination in sartan drugs using Agilent's innovative triple quadrupole (TQ) GC/MS system with hydrogen carrier gas

Nitrosamine impurities in pharmaceutical compounds are a critical concern due to their potential carcinogenicity. This application note presents an advanced method for the efficient detection and quantification of nitrosamine impurities in sartan drugs, leveraging an Agilent GC/TQ system with hydrogen as the carrier gas. The study highlights the efficacy of hydrogen as a sustainable alternative to helium, demonstrating comparable performance while mitigating challenges associated with helium scarcity.

Read the full application note here.

  • Companies:
  • Agilent Technologies
See more

You may also like

Manufacturing

Modernising the USP HPLC method for acetaminophen and caffeine tablets

Read more
New approach to USP guidelines delivers faster analysis, reduced solvent use, and improved performance with no revalidation required.

Trending Articles

  1. You need to be a subscriber to read this article.
    Click here to find out more.
    Opening new doors to precision medicine with single-stranded DNA (ssDNA): part I In this two-part article, the science behind ssDNA manufacturing is explored, along with the innovations that are enhancing the therapeutic benefits of ssDNA-derived constructs. A comparative analysis of traditional double-stranded DNA (dsDNA) and other nucleic acid-based methods is also included
  2. Johnson & Johnson to invest $55bn into US manufacturing, R&D and tech The company will build three new advanced pharmaceutical manufacturing facilities on top of its biologics manufacturing site in Wilson, North Carolina, which is currently under construction
  3. Three digital strategies to modernise quality control lab operations With the proliferation of quality control (QC) digital projects to improve lab efficiency, more QC leaders are adopting standalone applications that narrowly focus on a specific need. This can lead to individual labs using different tools to execute processes, making connectivity and unification difficult, reports Jason Boyd, Senior Director, Vault LIMS, Veeva Systems
  4. AstraZeneca puts $2.5bn into Chinese R&D and manufacturing capabilities The pharmaceutical giant will establish its sixth strategic R&D centre in China, as well as novel research and manufacturing agreements in the region
  5. Trump's pharma tariffs to be introduced "in the near future" President Donald Trump has announced that he will be introducing tariffs to pharmaceutical imports in the "very near future", though it's unclear if this will begin on April 2 as previously thought

Upcoming event

Interphex

1–3 April 2025 | Conference and Exhibition | New York, US See all

You may also like

Manufacturing

Modernising the USP HPLC method for acetaminophen and caffeine tablets

New approach to USP <621> guidelines delivers faster analysis, reduced solvent use, and improved performance with no revalidation required.
Research & Development

Transmission Raman Spectroscopy - access the webinar series today

Offering significant advantages for bulk, quantitative and non-destructive analysis, Transmission Raman Spectroscopy is a preferred choice for applications where surface analysis is insufficient or prone to errors. Speakers from Agilent, Novartis Pharma, AstraZeneca, Bristol-Myers Squibb and AbbVie go deeper in this FREE webinar series
Manufacturing

Dissolution of an immediate release nanoparticle formulation using the NanoDis system

An efficient dissolution method to aid in nanoparticle drug development
Analysis

Agilent and GenNext integrate digital technologies to accelerate biopharma research

The combination of the two systems will allow biopharmaceutical researchers to better analyse a protein's structure and function in the lab
Analysis

Agilent's chromatographic technologies make it easier

Don’t miss the opportunity to drive efficiency and reduce operational cost with USP 621 revisions
Analysis

The expert's guide to pharmaceutical impurity analysis

Download new eBook from Agilent now
Research & Development

Agilent announces AssayMAP Bravo Protein Sample Prep Workbench 4.0

Launch extends the use of AssayMAP to regulated environments
Subscribe now