Natoli Engineering Company has now included the Light Induced Fluorescence (LIF) Sensor in its new Tablet Compression Accessories Catalogue. The LIF Sensor was designed for blend uniformity and end-point detection during the blending of powders as well as for liquid applications, including cleaning validation.
The advanced technology of the LIF Sensor has enabled real-time monitoring of fluorophore solutes via intrinsic fluorescent sensing in the solid state that has not been previously possible.
The LIF Sensor provides remarkable sensitivity, a wide dynamic range, and low detection limits, resulting in improved product quality by reducing process upsets, lower annual product waste, improved root-cause analysis during manufacturing quality incidents often common within the pharmaceutical industry, improved process efficiency by reducing manufacturing processing time, and improved operator safety via an in-line approach.
‘Granulation sticking to tablet compression tooling and other contact surfaces is one of the biggest obstacles in tablet compression today,’ says Dale Natoli, vice president, Natoli Engineering. ‘With the need to increase manufacturing efficiencies while maintaining tablet quality, pharmaceutical companies are favouring direct compression formulas, which contribute to the sticking issues.
‘The LIF sensor gives tablet manufacturers the capability to ensure blending uniformity prior to tablet production, thus reducing product waste and labour.’
Since fluorescence is approximately 1,000 times more sensitive than absorbance spectroscopy, the LIF Sensor can accurately measure residual Active Pharmaceutical Ingredients (APIs) in both rinse water and directly on surfaces. This field analysis capability provides near real-time cleaning validation and eliminates the need to swab and send samples to the lab for High Performance Liquid Chromatography (HPLC) analysis, which can take days, or even weeks.
Easily adaptable to different types of pharmaceutical blenders, the LIF Sensor’s integral accelerometer technology can determine the X-Y axis rotation of a Bin Blender or the Y-Z rotation of a V-Blender. The small, self-contained design and multifaceted mechanical and automation attributes provide for a robust sensor that is field deployable across a wide range of manufacturing scenarios.