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Market Reports
IntelGenx: oral films are drug development’s patent trick
Exploiting improvements in bioavailability, the Canadian company has developed unique oral film technology to help drugmakers secure exclusivity and financial returns
How to avoid sticking and picking in the tableting industry
John Norman and Kevin Queensen of Natoli Engineering explain
Super early bird tickets now on sale for Manufacturing Chemist Live 2020
Manufacturing Chemist Live will provide guidelines and regulations for delegates seeking solutions to optimise pharmaceutical production and safety in the manufacturing environment
Distributed control system reduces downtime for pharmaceutical manufacturer
In this case study, Rockwell Automation describes how Mallinckrodt Pharmaceuticals was able to streamline production and pinpoint potential bottlenecks by implementing a virtualised control system architecture
Flexibility through standardisation
The global pharmaceutical industry is going through a significant transformation, shifting from blockbuster drugs to personalised medicines based on biotechnology and genomics
There’s more than one way to produce pharmaceutical water
Bosch Packaging’s Susanne Handrick and Nils Ern examine the potential of cold membrane processes for the production of pharmaceutical water for injection
Winner of the Nobel Prize in Physiology or Medicine
William Kaelin Jr, Sir Peter Ratcliffe, and Gregg Semenza have won the Nobel Prize for Physiology or Medicine 2019 for their discoveries of how cells sense and adapt to oxygen availability
Medical cannabis made in Italy
Dr Fabio Di Francesco, a compounding pharmacist based in Rome, describes how cannabis is used in various dosage forms and the challenges ahead
Almac FAST: Continuous flow chemistry with assisted synthesis technology
Flow assisted synthesis technology (FAST) is a unique flow chemistry platform for continuous production of chemicals when batch-based processes fail to deliver the required quality of product
Peak identification by LC/MS: Automation versus analyst
High pressure liquid chromatography/mass spectrometry (LC/MS) is an important technique that facilitates the correct and accurate identification of impurities in pharmaceutical products and intermediates
Testing the limits of dosage production with continuous direct compression technology
GEA’s Dr James Holman, Head of New Development and Innovation, Pharma, discusses the process robustness and operational considerations of the company’s CDC 50 platform during a 120-hour trial run
Beximco Pharma: The Bangladeshi company connecting with the US
COO Rabbur Reza talks about the strategy behind approaching pharmaceutical manufacturing from an emerging market
Addressing the need for cost-effective vaccine manufacturing
Process intensification and integrated continuous bioprocessing are two approaches that can be used to achieve cost-effective, local production of high-quality biologic products. Tania Pereira-Chilima, Product Manager at Univercells, explains
Future market dynamics and opportunities in immuno-oncology
Long-term survival, tumour-agnostic effects and the potential for cure in a fraction of patients are key catalysts driving the explosion of research and recent approvals in IO. Dr Kevin Robinson recently caught up with SmartAnalyst’s Nidhi Dhingra and Jaideep V. Thottassery to delve a little deeper
A microfluidic approach to production of alginate beads for cell encapsulation
Gurinder Vinner, Material Scientist at Dolomite Microfluidics, discusses the benefits of continuous microfluidic production for the encapsulation of mammalian cells with no loss of viability
The case for single-use architecture in pharma
Billy Sisk, Life Sciences Industry Manager, EMEA, at Rockwell Automation recently contributed to the free downloadable e-book, the <i>Big Book of Biotech</i>, alongside input from GSK, Merck, ZeClinics and others. Here, for readers of <i>Manufacturing Chemist</i>, he picks up his topic of single-use facilities
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From stockpiles to smart supply chains: how industry wants to fix Europe’s drug shortages
An EU-level stockpile may work, but only if it’s flexible, closely monitored and built with logistics in mind. Industry players say drug security will depend less on volume and more on data, digital oversight and early collaboration throughout the supply chain
A grandmaster’s approach to successful tableting
Tableting is a fundamental unit operation in the production of pharmaceutical oral solid dosage forms. Despite its long history of use and the development of innovations such as extended dwell times, unique technologies that independently and simultaneously measure and control both tablet weight and hardness, and a weight control system that provides increased sensitivity at lower forces, production problems still occur. Here, Dr Harald Stahl, Group Director, Application and Strategy Management, GEA, provides some troubleshooting tips from an unlikely source: the chess board
The modularisation of chemical API synthesis
The modularisation of chemical synthesis pathways in pharmaceutical production can improve overall plant efficiency and reduce planning time. Glatt Ingenieurtechnik has optimised the active pharmaceutical ingredient (API) synthesis process and developed bespoke plant designs for several international customers
Leaders of transformation
Haig Armaghanian, founder and CEO of Haig Barrett, explores how synthetic biology pioneers are revolutionising therapeutic development
Is the production of biologic drugs ready for an overhaul?
Is the industry ready for a new manufacturing model? Mark Emalfarb, President and CEO of Dyadic International, thinks so and explains why to Dr Kevin Robinson
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