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Market Reports
IntelGenx: oral films are drug development’s patent trick
Exploiting improvements in bioavailability, the Canadian company has developed unique oral film technology to help drugmakers secure exclusivity and financial returns
How to avoid sticking and picking in the tableting industry
John Norman and Kevin Queensen of Natoli Engineering explain
Super early bird tickets now on sale for Manufacturing Chemist Live 2020
Manufacturing Chemist Live will provide guidelines and regulations for delegates seeking solutions to optimise pharmaceutical production and safety in the manufacturing environment
Distributed control system reduces downtime for pharmaceutical manufacturer
In this case study, Rockwell Automation describes how Mallinckrodt Pharmaceuticals was able to streamline production and pinpoint potential bottlenecks by implementing a virtualised control system architecture
Flexibility through standardisation
The global pharmaceutical industry is going through a significant transformation, shifting from blockbuster drugs to personalised medicines based on biotechnology and genomics
There’s more than one way to produce pharmaceutical water
Bosch Packaging’s Susanne Handrick and Nils Ern examine the potential of cold membrane processes for the production of pharmaceutical water for injection
Winner of the Nobel Prize in Physiology or Medicine
William Kaelin Jr, Sir Peter Ratcliffe, and Gregg Semenza have won the Nobel Prize for Physiology or Medicine 2019 for their discoveries of how cells sense and adapt to oxygen availability
Medical cannabis made in Italy
Dr Fabio Di Francesco, a compounding pharmacist based in Rome, describes how cannabis is used in various dosage forms and the challenges ahead
Almac FAST: Continuous flow chemistry with assisted synthesis technology
Flow assisted synthesis technology (FAST) is a unique flow chemistry platform for continuous production of chemicals when batch-based processes fail to deliver the required quality of product
Peak identification by LC/MS: Automation versus analyst
High pressure liquid chromatography/mass spectrometry (LC/MS) is an important technique that facilitates the correct and accurate identification of impurities in pharmaceutical products and intermediates
Testing the limits of dosage production with continuous direct compression technology
GEA’s Dr James Holman, Head of New Development and Innovation, Pharma, discusses the process robustness and operational considerations of the company’s CDC 50 platform during a 120-hour trial run
Beximco Pharma: The Bangladeshi company connecting with the US
COO Rabbur Reza talks about the strategy behind approaching pharmaceutical manufacturing from an emerging market
Addressing the need for cost-effective vaccine manufacturing
Process intensification and integrated continuous bioprocessing are two approaches that can be used to achieve cost-effective, local production of high-quality biologic products. Tania Pereira-Chilima, Product Manager at Univercells, explains
Future market dynamics and opportunities in immuno-oncology
Long-term survival, tumour-agnostic effects and the potential for cure in a fraction of patients are key catalysts driving the explosion of research and recent approvals in IO. Dr Kevin Robinson recently caught up with SmartAnalyst’s Nidhi Dhingra and Jaideep V. Thottassery to delve a little deeper
A microfluidic approach to production of alginate beads for cell encapsulation
Gurinder Vinner, Material Scientist at Dolomite Microfluidics, discusses the benefits of continuous microfluidic production for the encapsulation of mammalian cells with no loss of viability
The case for single-use architecture in pharma
Billy Sisk, Life Sciences Industry Manager, EMEA, at Rockwell Automation recently contributed to the free downloadable e-book, the <i>Big Book of Biotech</i>, alongside input from GSK, Merck, ZeClinics and others. Here, for readers of <i>Manufacturing Chemist</i>, he picks up his topic of single-use facilities
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Performance validation: HPAPI containment testing in a risk-based era
Taking a more automated approach to validation testing paves the way to capturing more repeatable and reliable data, thereby improving levels of containment performance
Single-pass tangential flow filtration: A versatile approach to streamlining biomanufacturing
Current trends in the biopharmaceutical industry are driving the implementation of high capacity processes that are capable of reducing costs and equipment footprint without sacrificing manufacturing efficiency and product quality
Building a new business model with method lifecycle management
An increased focus on lifecycle management for analytical methods has been seen in recent years from the industry’s regulatory bodies. Method lifecycle management (MLCM) provides an opportunity to continuously improve and ensure quality of data through the application of quality risk management
How to avoid sticking and picking in the tableting industry
John Norman and Kevin Queensen of Natoli Engineering explain
Recombinant versus synthetic peptide synthesis: the perks and drawbacks
Since the introduction of novel peptide drugs into the market, the demand for polypeptide manufacturing has significantly increased, reports Dr Philipp Markolin