Avecia invests $100m in biologics manufacturing
One of the world's most advanced manufacturing facilities for biologics medicines is to be built at Billingham in the UK by Avecia. The US$100m (€113m) investment is the largest single spend by Avecia since its formation three years ago and will create 40,000l of contract manufacturing capacity for microbially derived biologics. The new plant will complement the Advanced Biologics Centre (ABC) and major process development team at Avecia's existing Billingham facility and will establish the company as a global leader in biologics contract manufacturing with integrated capability for development, trials and large-scale manufacturing to cGMP standards on a single site.
Stage one, which is due to come on stream in the third quarter of next year, will consist of two 5,000l capacity fermentation streams, each with independent separation and purification suites, to offer multi-product manufacturing capability. The second stage will add two 15,000l fermenters and associated purification streams, due to come on stream by 2005, enabling the plant to run four large-scale manufacturing campaigns simultaneously.
The new plant is to be built with flexibility in mind and with a view to expansion to help customers meet unpredictable demand schedules as products progress through clinical trials. Biologics currently account for more than 20% of all new drug approvals, and there are more than 250 microbially derived biologic medicines in clinical trials at present. Current global capacity is close to full utilisation, while demand by the healthcare industry for contract manufacturing of biologics is forecast to more than double to at least $700m (€792m) by 2005.