Boehringer Ingelheim and Medivir sign agreement for novel HIV/AIDS antiviral

Published: 16-Jul-2003

Swedish company Medivir has out-licensed its innovative HIV antiviral MIV-310 to Boehringer Ingelheim, of Germany.


Swedish company Medivir has out-licensed its innovative HIV antiviral MIV-310 to Boehringer Ingelheim, of Germany.

Currently in Phase II clinical development, MIV-310 is an extremely potent inhibitor of reverse transcriptase and belongs to the nucleoside analogue class (NRTI). In contrast to conventional nucleoside analogues, preclinical and clinical results show that MIV-310 has a unique activity against multi-drug resistant HIV-1.

Under the terms of the agreement, Boehringer Ingelheim will make upfront and milestone payments to Medivir of up to €122m (US$136m). Medivir will also receive a double-digit royalty on product sales. Boehringer Ingelheim receives exclusive global marketing rights outside the Nordic countries (Sweden, Denmark, Finland, Norway, and Iceland), which are retained by Medivir. Responsibility for pharmaceutical and clinical development rests with Boehringer Ingelheim.

'We look forward to collaborating with Medivir on MIV-310,' said Dr Andreas Barner, member of the management board of Boehringer Ingelheim, responsible for research & development and medicine. 'Together with the marketed non-nucleoside reverse transcriptase inhibitor Viramune, and the protease inhibitor tipranavir, currently in Phase III of clinical development, MIV-310 will complement Boehringer Ingelheim's HIV drug development portfolio.'

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