InNexus unveils antibody platform

Published: 7-Aug-2007
Research & Development

InNexus Biotechnology has announced that enhancement of critical performance factors for many monoclonal antibodies (MAbs) appears possible with its new cross linking technology.


InNexus Biotechnology has announced that enhancement of critical performance factors for many monoclonal antibodies (MAbs) appears possible with its new cross linking technology.

Laboratory studies of the company's first product candidate, DXL625 (CD20), for the prospective treatment of non-Hodgkin's lymphoma, indicated that DXL625, an anti-CD20 monoclonal antibody enhanced with InNexus" DXL technology, may afford greater potency, binding affinity, and related characteristics, than the parent compound.

The data were presented as part of the Cancer Track at the IBC Life Science Drug Discovery and Development of Innovative Therapeutics (DDT) Conference in Boston, US.

The InNexus study utilised CD20 antibodies integrated with DXL-peptide. The modified antibodies were observed to have a higher binding affinity than the parent molecule. DXL-anti-CD20 antibodies were also seen as more potent inducers of apoptosis in cell-based assays. DXL-anti-HER2 antibodies were significantly more potent than the parent antibody in slowing tumour progression in a xenograft disease model.

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