Lonza launches GS Effex cell line to develop therapeutic antibodies with increased potency

Published: 14-Nov-2023

The new cell line is designed to help overcome challenges in immunotherapy research and development related to the need for antibody therapeutics to have increased potency

The GS Effex cell line was developed to meet pressing market needs originating from the shift towards more sophisticated therapeutic antibodies.

Derived from Lonza’s leading GS Xceed cell line, GS Effex fits effectively into Lonza platforms.

Combined with good cell growth and the ability to produce therapeutic antibodies with increased potency, the new cell line provides a solution for therapeutic development from discovery stage research through to commercial manufacturing.

This stable, scalable and productive cell line produces Fc domains free from fucose, which increases the antibody dependent cellular cytotoxicity (ADCC) function and therapeutic potency of the final antibody. GS Effex is available under license or as a complete service offering.

Ulrich Osswald, Vice President, Licensing, Lonza, commented: "Lonza is committed to providing our customers with the right tools to develop their novel therapies."

"Leveraging more than 35 years of protein expression expertise, more than 75 molecules have been manufactured and brought to the clinic using our expression platforms."

"The new GS Effex cell line represents an enhanced solution especially relevant for the oncology field as improved ADCC represents a vital enhancement of the therapeutic success of an antibody product."

Atul Mohindra, Head of Biologics R&D, Lonza, added: “At Lonza, we develop and invest in novel, disruptive technologies with potential to transform the development, analytics, and manufacturing of established and novel biotherapeutics."

"The GS Effex cell line provides a reliable protein expression platform with the needs of our customers in mind. This cell line enables the efficient production of monoclonal antibodies with increased ADCC, while also delivering the required product quality and efficacy profile.”

Lonza's industry-leading GS Gene Expression System builds on more than 35 years of expertise in mammalian expression, process development, and technical and manufacturing expertise, supported by continuous innovation.

The system includes Lonza's proprietary host cell lines, GS Xceed and GS Effex, GS piggyBac transposon technology, GS Discovery transient expression system, vectors, optimized processes and extensive expertise.

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