Scientists at the University of Bath and the burns team at the Southwest UK Paediatric Burns Centre at Frenchay Hospital in Bristol are working with teams across Europe and Australia to create the dressing.
The dressing will work by releasing antibiotics from nanocapsules triggered by the presence of pathogenic bacteria, targeting treatment before the infection takes hold.
The dressing will also change colour when the antibiotic is released, alerting medical staff that there is infection in the wound.
This development will be an important step in treating burns patients, particularly children, where infections can lead to toxic shock syndrome, a potentially fatal condition.
The €4.5m European Commission-funded project is a collaboration of 11 partners coordinated by Dr Renate Förch at the Max-Planck-Institute for Polymer Research (Germany), which will develop the prototype dressing over the next four years.
The Bacteriosafe project includes chemists, cell biologists, clinicians and engineers, who will not only develop the dressing, but also work with industry on a pre-pilot scale manufacturing process, which means they could be available on the market within a few years after completion of the project.
University of Bath project leader, Dr Toby Jenkins said: ‘Your skin is normally home to billions of ‘friendly’ bacteria, which it needs to stay healthy. The dressing is only triggered by disease-causing bacteria, which produce toxins that break open capsules containing the antibiotics and dye.
‘This means that antibiotics are only released when needed, which reduces the risk of the evolution of new antibiotic-resistant super-bugs such as MRSA.’
Dr Amber Young, a paediatric burn specialist at the South West UK Paediatric Burn Centre, is the clinical consultant on the project.
‘This advanced dressing will speed up treatment because it is automatically triggered to release antibiotics only when the wound becomes infected, meaning that the dressing will not need to be removed, thereby increasing the chances of the wound healing without scarring.
‘The colour change acts as an early warning system that infection is present, meaning we can treat it much faster, reducing the trauma to the child and cutting the time they have to spend in hospital.’
The dressing could also be used for other types of wound, such as ulcers, or by the military on the battlefield.
The researchers have already tested fabric coated with the nanocapsules, which are just one millionth of a millimetre in size. They have been shown to react specifically to harmful bacteria.