MilleGen and LFB to develop MAbs

Published: 23-Mar-2007

MilleGen, a French biopharmaceutical company focused on Directed Molecular Evolution (DME), and LFB, a leading pharmaceutical supplier to French hospitals, are to design a new generation of recombinant monoclonal antibodies (MAbs).


MilleGen, a French biopharmaceutical company focused on Directed Molecular Evolution (DME), and LFB, a leading pharmaceutical supplier to French hospitals, are to design a new generation of recombinant monoclonal antibodies (MAbs).

In order to achieve this, MilleGen and LFB will work to improve the MAbs pharmacokinetics and effectors functions, which play a key role in their therapeutic capacity.

The deal brings together MilleGen's DME platform Mutagen and LFB's knowhow and expertise in therapeutic antibody discovery and development. MilleGen will apply its Mutagen technology to genetically engineer the Fc region of the antibody as a first phase of the project. The second step will involve LFB conducting pre-clinical evaluation of antibody candidates, in particular in the field of oncohematology.

The project led by MilleGen and LFB will also include an academic laboratory (Inserm U858, Toulouse, France), involved in the molecular and cellular engineering of recombinant antibodies.

Both partners obtained grants from the French government for this r&d project. Financial terms and conditions were not disclosed.

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