OncoMethylome and Abbott to profile DNA tumours

Published: 21-Dec-2007
Manufacturing Analysis

A Belgian molecular diagnostics company with expertise in developing gene methylation tests for treating cancer is helping Abbott to profile tumours.


A Belgian molecular diagnostics company with expertise in developing gene methylation tests for treating cancer is helping Abbott to profile tumours.

As part of this pharmacogenomic service collaboration, OncoMethylome Sciences in Liege will be testing its DNA methylation biomarkers on Abbott's biological samples.

Methylation is a natural control mechanism that regulates gene expression in DNA. Abnormal methylation of certain genes can silence gene expression and is associated with cancer development and response to cancer therapy. Genes whose methylation is linked to cancer are often called methylation biomarkers. Methylation biomarkers intended for use in companion diagnostics are associated with response to cancer drug therapy. OncoMethylome owns proprietary technology that is highly sensitive and capable detecting methylation biomarkers, and is also very suitable for testing these markers in a high- throughput manner on clinical samples.

Financial details of this new agreement have not been disclosed.

"We are very pleased to add this collaboration to existing similar agreements and to use our high-throughput methylation platform to efficiently test our methylation biomarkers on

biological samples provided by Abbott," said Dr Jim DiGuiseppi, chief technology officer of OncoMethylome. "We are pleased that Abbott has chosen OncoMethylome and our methylation technology for this collaboration."

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